Publications

Paul Leeson has published more than 150 papers, patents and book chapters, and has led drug discovery efforts in the cardiovascular, neuroscience, inflammation and respiratory therapy areas.

Please find some selected publications below.


Year: 2016
Description:
Quality guidelines for oral drug candidates: dose, solubility and lipophilicity. M. K. Bayliss, J. Butler, P. L. Feldman, D.V.S. Green, P. D. Leeson, M. R. Palovich, A. J. Taylor, Drug Discovery Today
Link: Please click here to view publication.

Year: 2016
Description:
Molecular inflation, attrition and the rule of five. P.D. Leeson, Advanced Drug Delivery Reviews
Link: Please click here to view publication.

Year: 2015
Description:
An analysis of the attrition of drug candidates from four major pharmaceutical companies. M. J. Waring, J. Arrowsmith, A. R. Leach, P.D. Leeson, S. Mandrell, R.M. Owen, G. Pairaudeau, W. D. Pennie, S. D. Pickett, J. Wang, O. Wallace and A. Weir. Nature Reviews Drug Discovery
Link: Please click here to view publication.

Year: 2014
Description:
The role of ligand efficiency metrics in drug discovery. A. L. Hopkins, G.M. Keserü, P.D. Leeson, D.C. Rees, C.H. Reynolds. Nature Reviews Drug Discovery
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Year: 2011
Description:
The ‘organisational factor’ in drug design: an assessment of target-unbiased compound quality. P.D. Leeson & S.A. St-Gallay, Nature Reviews Drug Discovery
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Year: 2007
Description:
The influence of drug-like concepts on decision-making in medicinal chemistry. P.D. Leeson and B. Springthorpe, Nature Reviews Drug Discovery
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Year: 2007
Description:
From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. B. Springthorpe, A. Bailey, P. Barton, T.N. Birkinshaw, R.V. Bonnert, R.C. Brown, D. Chapman, J. Dixon, S.D. Guile, R.G. Humphries, S.F. Hunt, F. Ince, A.H. Ingall, I.P. Kirk, P.D. Leeson, P. Leff, R.J. Lewis, B. Martin, D.F. McGinnity, N.P. Mortimore, S.W. Paine, G. Pairaudeau, A. Patel, A.J. Rigby, R.J. Riley, B.J. Teobald, W. Tomlinson, P.J. H. Webborn and P.A. Willis, Bioorg. Med. Chem. Lett
Link: Please click here to view publication.